Anti Estrogens

Anti Estrogens is a substance that blocks the production or utilization of estrogens, or inhibits their effects. Estrogens are the family of hormones that promote the development and maintenance of female sex characteristics.

Although aromatase inhibitors could be considered antiestrogens by some definitions, they are often considered to be a distinct class. Aromatase inhibitors reduce the production of estrogen, while the term "Anti Estrogens" is usually reserved for agents reducing the response to estrogen.

Hot flashes, osteoporosis, breast atrophy, and vaginal dryness can be side effects of Anti Estrogens.

Anti Estrogens like tamoxifen can promote an invasive phenotype in estrogen receptor (ER)-positive breast cancer cells with deficient intercellular adhesion.

Ethamoxytriphetol was the first Anti Estrogens to be discovered, followed by clomifene citrate and tamoxifen. Fulvestrant is another Anti Estrogens, and is the only pure Anti Estrogens, or silent antagonist of the estrogen receptor, to have been introduced clinically.

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